The Gipuzkoa Alzheimer Project (PGA) is a longitudinal study on pre-clinical Alzheimer's disease.
Within the framework of the PGA study and in partnership with the Neuroimaging team from the Department of Radiology and Nuclear Medicine, the free University of Amsterdam led by Professor Frederik are researching potential neuroimaging markers using magnetic resonance through the analysis of volumetrics, structural network analysis and functional magnetic resonance analysis in resting states, both in relation to the situation involving an increased risk of AD (family history and/or APOE status) and AD biomarkers in cerebrospinal fluid.
To research the presence of changes in the microstructure of the tracts of the white substance in participants from the Basque PGA study cohort with increased risk of AD through analysis of diffusion tensor imaging (DTI). To analyse the association between the inter-individual variability in the total cholesterol levels, HDL, LDL) and triglycerides in blood with the changes in the DTI.
To design a tool for health education of the population in the early identification of Alzheimer's Disease.
To research the role of following a Mediterranean diet and physical activity as protective factors and their association with the levels of AD biomarkers in cerebrospinal fluid and cognitive outputs in participants of the Basque PGA study cohort.
To search for neuropsychological markers of pre-clinical Alzheimer's disease through the analysis of the neuropsychological traits that define the cognitive profile of those with increased risk of AD (family history, APOE status, CAIDE index of risk of dementia) and people with pre-defined clinical biomarkers in cerebrospinal fluid.
To research the role of arterial hypertension as a risk factor and the systemic and cerebral renin-angiotensin as pathophysiologic markers of pre-clinical AD through analysis of its effect on AD biomarkers in cerebrospinal fluid.
To analyse the effect of bilingualism acquired at different ages compared to monolingualism on cognitive outputs and biomarkers profiles of AD in cerebrospinal fluid in the PGA Basque study cohort of participants
To analyse biological signals related to prosody, emotional temperature and phonological aspects of discourse as neurodegenerative disease markers.
To analyse the feasibility and impact of complications associated with the performance of the lumbar puncture in the context of Alzheimer's disease care and research.
To research the prevalence of positivity in the cerebrospinal fluid AD biomarkers in cognitively healthy subjects. Multicentre Study
To design a semi-quantitative sub-scale to complement Scheltens and collaborators' medial temporal atrophy scale for the evaluation of low levels of atrophy in cognitively healthy subjects. To research the association of those grades from the new sub-scale with cognitive outputs and AD biomarkers in subjects participating in the Basque PGA cohort study

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