Cita Alzheimerwww.cita-alzheimer.org

3. Who are the Alzheimer's disease prevention strategies aimed at? Cross sectional study of the risk factor profile for pre-clinical Alzheimer's disease (PREVALZ)

Principal Researcher Pablo Martínez-Lage

Status: Completed

Purpose: To research the profile of cardiovascular risk factors in people with pre-clinical Alzheimer's disease.

Interim results: A significant arterial hypertension effect (OR=2.4; CI95% [1.13-5.25]; p < 0.05) on the classification of a participant as LCR-A β + was observed in the logistic regression model adjusted according to age (greater or less than the sample median), APOE genotype (carrier or non-carrier of E4) and sex. The A1-42 levels were significantly different among participants with and without hypertension (789.3 ± 220.3 pg/mL vs. 849.7 ± 215.5 pg/ml; p<0.05 ).

In the logistic regression analysis adjusted according to age (greater or less than the sample median of 57.2 years of age), sex, and APOE status (non-carrier, carrier), a significant effect on the classification of a participant was observed as LCR--Aβ + of the REGICOR cardiovascular risk index (risk <5% vs ≥ 5%) (OR=2.2; CI95[1.00-4.97]; p<0,05). There was also a significant effect of the SCORE risk index (OR=1.63; CI95 [1.07-2.55]; p<0.05); and the same was observed with the Framingham risk index (OR=2.54; CI95 [1.31-5.07]; p<0.01).

Funding entity: Basque Government SAIOTEK 2013 call. Project no.: S-PR13ZH001
 

We use own and third party cookies to improve our services and show related advertising to your preferences by analyzing your browsing habits. If you continue browsing, we consider that you accept the use.
You can change the settings or get more information here.