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2. Functional and structural magnetic resonance neuro-imaging in pre-clinical Alzheimer's disease.

Status: Ongoing

Within the framework of the PGA study and in partnership with the Neuroimaging team from the Department of Radiology and Nuclear Medicine, the free University of Amsterdam led by Professor Frederik are researching potential neuroimaging markers using magnetic resonance through the analysis of volumetrics, structural network analysis and functional magnetic resonance analysis in resting states, both in relation to the situation involving an increased risk of AD (family history and/or APOE status) and AD biomarkers in cerebrospinal fluid.

Substudies:

  • Grey matter network disruptions and Alzheimer’s Disease pathology in non-demented elderly (Dr. Betty Tijms, VUMC).
  • Impact of APOE-ɛ4 and family history of dementia on gray matter atrophy in cognitively healthy middle-aged adults (Dr. Mara ten Kate, VUMC)
  • Functional brain network eigenvector centrality differences between different risk groups for Alzheimer's Disease (Dr. Alle Meije Wink, )
  • Altered resting state network activity related to network-specific cognitive performance in different groups at risk for developing Alzheimer's disease. (Dr. Ernesto San-Arigita)

 

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